Glucose variability in 6–12-month-old healthy infants

Background Metabolic programming of glucose homeostasis in the first 1,000 days life may impact lifelong metabolic and cardiovascular health. Continuous monitoring (CGM) devices help measure dietary intake on rhythms metabolism infants during complementary feeding period. Objectives Demonstrate feasibility CGM to quantify variability response infant evaluate associations between macronutrient meal composition variability. Methods The “FreeStyle Libre Pro ® ” device interstitial meter was applied anterior thigh 10 healthy 6–12-month-old infants. Parents recorded food intake, time feeding, used daily dairies record sleep duration. Descriptive statistics were employed for key glycemic parameters over three full days. Mixed linear models assess changes. Results Mid-day, afternoon, evening feeds contained >30 g carbohydrate induced higher 2-h iAUC (3.42, 3.41, 3.50 mmol/L*h respectively) compared early mid-morning feedings with ≤25 carbohydrates (iAUC 2.72 2.81 mmol/L*h, p < 0.05). Early morning milk approximately 9 fat a longer reach maximal value (Tmax; 75 68 min, lower (2.9–5.9 g; Tmax range: 34–60 min; Incremental at (C0) increased significantly from 0.24 ± 0.39 mM 1.07 0.57 ( Over day, 70% values remained within normal range (3.5–5.5 mmol/L), 10% 5.5–10 mmol/L, 20% 3.5 mmol/L. Conclusion Our data support using observation possible diurnal typical have implications future studies investigating adaptation nutritional life.